Dynamic and plasmonic response exhibited by Au nanoparticles suspended in blood plasma and cerebrospinal fluids

Abstract Herein are reported nonlinear optical effects and optical spectroscopy studies for identifying particular modifications in blood plasma and cerebroespinal fluids with plasmonic nanoparticles. The influence of the explored biofluids on the absorption band related to the Surface Plasmon Resonance exhibited by Gold nanoparticles was analyzed. The Gold nanoparticles were synthetized by a sol-gel method and characterized by Scanning Electronic Microscopy. It was found that the evolution of the plasmonic and third-order nonlinear optical response of the nanoparticles present characteristic signatures that can be related to interparticle effects and flow velocity in biofluids. It was demonstrated a dynamic and nonlinear optical behavior exhibited by the nanoparticles with higher sensitivity than spectroscopic measurements for detecting healthy and unhealthy human fluids related to particular medical diagnosis of donors. We highlighted the impact of these results for opening the possibility for engineering advanced nanomedicine vehicles with potential applications in delivery, tracking and therapy by the assistance of plasmonic nanoparticles interacting with biological media. Advantages exhibited by ultrafast two-wave mixing experiments for diagnostic functions and nanomedicine applications in nanofluids can be contemplated.