Administration of Tetrahydrobiopterin (BH4) Protects the Renal Microcirculation from Ischemia and Reperfusion Injury

BACKGROUND:Abdominal aortic aneurysm surgery with suprarenal cross-clamping is often associated with renal injury. Although the mechanism underlying such injury is unclear, tissue ischemia and reperfusion, which induces endothelial dysfunction and decreases the availability of tetrahydrobiopterin (B