Haemato–Biochemical and Histo–Pathological findings of Fibrin–Chitosan Composite Biocasings Application on Cutaneous Wound Healing in Dogs

Twelve dogs with cutaneous wounds presented to the clinic were randomly divided into two groups of six animals each to evaluate fibrin - chitosan composite biocasings for cutaneous wound healing. The biocasings were evaluated based on haematological, biochemical and histological studies conducted at different periods of observation. Haematoloical and Biochemical parameterrs showed transient initial significant changes which were due to stress in control group and due to additional presence of fibrin - chitosan foreign material in treated group. the sequence of events of histological healing viz, inflammatory reaction, fibrovascular proliferation and epithelization were more evident in fibrin - chitosan treated wounds. the biocasings were adherent to the wound surface producing good haemostatic effect. it was concluded that the fibrin - chitosan composite biocasings for cutaenous wound healing was effective without any adverse effects.