Abstract TP332: Hypoxia-Inducible Factor 1-Alpha (HIF1α)-Mediated Phosphoenolpyruvate (PEP) Carboxykinase-1 (PCK1) Upregulation & Metabolic Injury in Stroke

Eric E Cosky,Longfei Guan,Jiamei Shen,Xiaokun Geng,Yuchuan Ding

Abstract TP332: Hypoxia-Inducible Factor 1-Alpha (HIF1α)-Mediated Phosphoenolpyruvate (PEP) Carboxykinase-1 (PCK1) Upregulation & Metabolic Injury in Stroke

2019

Eric E Cosky
Longfei Guan
Jiamei Shen
Xiaokun Geng
Yuchuan Ding

Introduction: In acute ischemic stroke (AIS), neurons upregulate glycolysis in an attempt to meet their energy demands, which causes lactic acidosis and reactive oxygen species (ROS) formation. The...

Keywords:

Physical therapy
Phosphoenolpyruvate carboxykinase
Downregulation and upregulation
Stroke
Endocrinology
PCK1
Diabetes mellitus
Internal medicine
Medicine
Hypoxia-Inducible Factor 1-Alpha
Reactive oxygen species
Hypoxia (medical)
Lactic acidosis
Glycolysis

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