PCK1

1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV510518534ENSG00000124253ENSMUSG00000027513P35558Q9Z2V4NM_002591NM_011044NP_002582NP_035174Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.1khb: PEPCK complex with nonhydrolyzable GTP analog, native data1khe: PEPCK complex with nonhydrolyzable GTP analog, MAD data1khf: PEPCK complex with PEP1khg: PEPCK1m51: PEPCK complex with a GTP-competitive inhibitor1nhx: PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR2gmv: PEPCK complex with a GTP-competitive inhibitor Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene. This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized. Click on genes, proteins and metabolites below to link to respective articles.