Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

Katarina S.Midelfort1,4, Rajesh Kumar1, Seungil Han1,4, Michael J.Karmilowicz1, Kevin McConnell1, Daniel K.Gehlhaar2, Anil Mistry1, Jeanne S.Chang1, Marie Anderson1, Alan Villalobos3, Jeremy Minshull3, Sridhar Govindarajan3 and John W.Wong1 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA, Pfizer Worldwide Research and Development, 10555 Science Center Drive, San Diego, CA 92121, USA and DNA 2.0, 1140 O’Brien Drive, Suite A, Menlo Park, CA 94025, USA