Nitroxyl radical-catalyzed chemoselective alcohol oxidation for the synthesis of polyfunctional molecules

Abstract Alcohol oxidation is one of the most principal transformations used in organic synthesis. During the development of these oxidation methods, chemoselective oxidation of a specific alcohol in a polyol has enabled the discrimination of multiple hydroxy groups, which can increase the synthetic efficiency by reducing the use of protecting groups. This digest highlights recent topics of the catalytic systems using nitroxyl radicals for the chemoselective alcohol oxidation and the representative examples during the synthesis or derivatization of natural products.