Ameliorative role of Vitamin D on prenatal and postnatal exposure of monosodium glutamate induced steatohepatitis in rat pups
2018
Background: Monosodium glutamate (MSG) is a widely used flavor enhancer has been
linked to obesity and metabolic syndrome, including progressive liver disease. Nonalcoholic
Fatty Liver Disease (NAFLD) is the most common hepatic disorder with an etiology related to
changes in diet and lifestyle. Prenatal and postnatal exposure to MSG been shown to affect
developing tissues in growing animals. Increased Risk of Non-alcoholic Steatohepatitis has
been associated with Vitamin D deficiency. The present study was aimed to investigate the
ameliorative effect of vitamin D on MSG induced animal models of steatohepatitis in neonatal
rats. Materials and Methods: Eighteen nulliparous female wistar rats were randomly divided
into three groups (n=6/group). Group-I received a daily oral dose of 5g/kg body weight of
MSG. Group-II received the same dose of MSG along with calcitriol (0.2μg/kg BW). Group-III
was treated with saline served as the control. The rats could mate, and treatment was given
for the entire period of gestation and thirty days thereafter, during lactation. The histological
changes in the liver was observed. Results: Pan-lobular microvesicular steatosis, lobular
inflammation and ballooning of hepatocytes was observed in the MSG-treated group. These
histotoxic changes were ameliorated in the vitamin D treated group. Conclusion: Vitamin D
might be beneficial in the protection of the pre-and postnatal exposed MSG induced steatohepatitis.
Further, induction of steatohepatitis in a shorter period could also make it an ideal
study model of non-alcoholic steatohepatitis.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
1
Citations
NaN
KQI