Pholcodine-induced Stevens-Johnson syndrome in a patient with COVID-19.

Stevens-Johnson syndrome (SJS) is a hypersensitivity reaction with a distinctive clinical pattern characterised by targetoid skin lesions and lesions of at least two anatomic mucosal membranes sites. It is usually triggered by certain drugs, for example, allopurinol, antibiotics (mostly sulfonamides), nonsteroidal anti-inflammatory drugs and aromatic anticonvulsants.1 Most patients show evidence of SJS 7 to 21 days after the first drug exposure.1 Viral infections such as COVID-19 might also induce SJS.2 3 Drug eruptions are often clinically indistinguishable from viral infections.4 We present the case of drug-induced Stevens-Johnson syndrome in a patient with COVID-19. A 23-year-old Caucasian female patient was admitted to our hospital due to oral and genital erosions accompanied by erythematous macules with central dusky violaceous region on her thorax, face, lower extremities, palms and soles. Prior to development of skin lesions, the patient reported symptoms of high fever, pronounced malaise and headache, which were treated …