Detection method of sorafenib and related substances thereof

The invention relates to a detection method of sorafenib and related substances thereof. The method comprises the following steps of adopting a high performance liquid chromatography to carry out gradient elution, selecting an octadecylsilane chromatographic column, adopting a buffer solution with pH being 2.0 to 3.0 as a mobile phase A, and adopting a mixture of acetonitrile and ethyl alcohol as a mobile phase B, wherein the detection wavelength is 230nm to 240nm. The method has the characteristics of smooth and steady blank base line, strong specificity, good separation degree, high sensitivity, high accuracy, favorable precision, wide linearity range and the like, and is applicable to detecting the sorafenib or salts thereof and intermediate impurities thereof.