Knockout of Na-glucose-cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase-1 in macula densa and glomerular hyperfiltration

Panai Song,Winnie Huang,Akira Onishi,Rohit Patel,Young Chul Kim,Charlotte van Ginkel,Yiling Fu,Brent Freeman,Hermann Koepsell,Scott C. Thomson,Ruisheng Liu,Volker Vallon

Knockout of Na-glucose-cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase-1 in macula densa and glomerular hyperfiltration

2019

Panai Song
Winnie Huang
Akira Onishi
Rohit Patel
Young Chul Kim
Charlotte van Ginkel
Yiling Fu
Brent Freeman
Hermann Koepsell
Scott C. Thomson
Ruisheng Liu
Volker Vallon

The Na-glucose-cotransporter SGLT1 mediates glucose reabsorption in late proximal tubules. SGLT1 also mediates macula densa-sensing of an increase in luminal glucose, which increases nitric oxide s...

Keywords:

Cotransporter
Renal glucose reabsorption
Downregulation and upregulation
Nitric oxide
Biochemistry
Diabetes mellitus
Endocrinology
Biology
NITRIC OXIDE SYNTHASE 1
Glomerular hyperfiltration
Internal medicine
Macula densa
NOS1
Nitric oxide synthase

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