NOS1

4D1N, 4UCH, 4UH5, 4UH6, 4V3U, 5ADF, 5ADG, 5ADI, 5FVX, 5FVW, 5FVU, 5FVV484218125ENSG00000089250ENSMUSG00000029361P29475Q9Z0J4NM_000620NM_001204213NM_001204214NM_001204218NM_008712NP_000611NP_001191142NP_001191143NP_001191147NP_032738Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.1b8q: SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE1f20: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION.1k2r: Structure of rat brain nNOS heme domain complexed with NG-nitro-L-arginine1k2s: Structure of rat brain nNOS heme domain complexed with NG-allyl-L-arginine1k2t: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-phenyl-isothiourea1k2u: Structure of rat brain nNOS heme domain complexed with S-ethyl-N- isothiourea1lzx: Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound1lzz: Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound1m00: Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound1mmv: Rat neuronal NOS heme domain with NG-propyl-L-arginine bound1mmw: Rat neuronal NOS heme domain with vinyl-L-NIO bound1om4: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND1om5: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH 3-BROMO-7-NITROINDAZOLE BOUND1p6h: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound1p6i: Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-aminopentyl)-N'-nitroguanidine bound1p6j: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound1p6k: Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound1qau: UNEXPECTED MODES OF PDZ DOMAIN SCAFFOLDING REVEALED BY STRUCTURE OF NNOS-SYNTROPHIN COMPLEX1qav: Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin Complex1qw6: Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.1qwc: Rat neuronal nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.1rs6: Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound1rs7: Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound1tll: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.1vag: Neuronal nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R174771zvi: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain1zvl: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain complexed with natural substrate L-Arg.1zzq: Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound1zzr: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound1zzu: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Bound2g6h: Structure of rat nNOS heme domain (BH4 bound) in the reduced form2g6i: Structure of rat nNOS heme domain (BH2-bound) in the reduced form2g6j: Structure of rat nNOS (L337N) heme domain (4-aminobiopterin bound) complexed with NO2g6k: Structure of rat nNOS heme domain (BH4 bound) complexed with NO2g6l: Structure of rat nNOS heme domain (BH2 bound) complexed with NO2g6m: Structure of rat nNOS heme domain (BH4 bound) complexed with CO2g6n: Strcture of rat nNOS heme domain (BH2 bound) complexed with CO2hx3: Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5--pentyl}-N'-nitroguanidine2hx4: Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene. Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of synthases that catalyze the production of nitric oxide (NO) from L-arginine. NO is a chemical messenger with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter and may be involved in long term potentiation. It is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. Neuronal NOS and macrophage NOS are distinct isoforms. Both the neuronal and the macrophage forms are unusual among oxidative enzymes in requiring several electron donors: flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), NADPH, and tetrahydrobiopterin. It has been implicated in asthma, schizophrenia and restless leg syndrome. It has also been investigated with respect to bipolar disorder and air pollution exposure. NOS1 has been shown to interact with DLG4 and NOS1AP. This article incorporates text from the United States National Library of Medicine, which is in the public domain.