Engineered chitosan–xanthan gum biopolymers effectively adhere to cells and readily release incorporated antiseptic molecules in a sustained manner

Abstract The polyelectrolyte complexes that contain anionic xanthan gum and cationic chitosan formed or coalesced into biopolymeric scaffolds. To increase the viscosity and adherent properties of the prepared scaffolds, chitosan–xanthan gum microspheres were prepared by coacervation. The coalesced biopolymer was mixed with CHX to form injectable antibacterial hydrogels. We successfully prepared a biocompatible, antiseptic, chitosan–xanthan gum-based biopolymer with a potential to be used as an effective local antiseptic for acute or chronic periodontitis.