Прогноз при диффузной В-крупноклеточной лимфоме: некоторые аспекты

Frequency of germinal center-associated (CD10, CD23, CD38) and non-associated (CD30) antigen expression has been studied in DLBcl patients (total number 338). Overall survival was better in CD10-negative (p=0,035) and CD23-negative (p=0,029) DLBcl groups. CD30 identified prognostically favourable group (p=0,02), and CD38 did not influence prognosis (p=0,34). A particular features of CD23+ group were younger age of patients, and rare 2 or more extranodal localizations; in CD38-group LDH levels were much frequently elevated (p=0,019). It was concluded that expression of germinal ceter markers expression in DLBcl is not always associated with better prognosis and expression of post-follicular antigens is not always associated with worse prognosis.