Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits
2018
Wind-up is a frequency-dependent increase in the response of spinal cord neurons, which is believed to underlie temporal
summation of nociceptive input. However, whether spinoparabrachial neurons, which likely contribute to the affective component of
pain, undergo wind-up was unknown. Here, we addressed this question and investigated the underlying neural circuit. We show that
one-fifth of lamina I spinoparabrachial neurons undergo wind-up, and provide evidence that wind-up in these cells is mediated in
part by a network of spinal excitatory interneurons that show reverberating activity. These findings provide insight into a polysynaptic
circuit of sensory augmentation that may contribute to the wind-up of pain’s unpleasantness.
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