Abstract 16292: Selective Platelet Protease-Activated-Receptor (PAR)1 and PAR4 Mediated Thrombin Desensitisation in the Elderly is Correlated With Inflammation and Chronic Thrombin Receptor Stimulation

Sonali R. Gnanenthiran,Gabrielle J. Pennings,Caroline J. Reddel,Heather Campbell,Justin Raymond Hamilton,Vivien M. Chen,Leonard Kritharides

Abstract 16292: Selective Platelet Protease-Activated-Receptor (PAR)1 and PAR4 Mediated Thrombin Desensitisation in the Elderly is Correlated With Inflammation and Chronic Thrombin Receptor Stimulation

2020

Sonali R. Gnanenthiran
Gabrielle J. Pennings
Caroline J. Reddel
Heather Campbell
Justin Raymond Hamilton
Vivien M. Chen
Leonard Kritharides

Introduction: Platelet activation, by adenosine diphosphate (ADP) via P2Y12 receptors and thrombin via PAR1 and PAR4, is a key therapeutic target in cardiovascular disease (CVD). The efficacy of an...

Keywords:

Adenosine diphosphate
Pharmacology
Platelet
Medicine
platelet activation
Thrombin
Protease-activated receptor
Thrombin receptor
Receptor
P2Y12

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