The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

Frédérique Végran,Hélène Berger,Romain Boidot,Grégoire Mignot,Mélanie Bruchard,Magalie Dosset,Fanny Chalmin,Cédric Rébé,Valentin Derangère,Bernhard Ryffel,Masashi Kato,Armelle Prévost-Blondel,François Ghiringhelli,Lionel Apetoh

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

2014

Frédérique Végran
Hélène Berger
Romain Boidot
Grégoire Mignot
Mélanie Bruchard
Magalie Dosset
Fanny Chalmin
Cédric Rébé
Valentin Derangère
Bernhard Ryffel
Masashi Kato
Armelle Prévost-Blondel
François Ghiringhelli
Lionel Apetoh

TH9 cells are associated with autoinflammatory diseases. Apetoh and colleagues demonstrate a molecular pathway which converts TH9 cells into potent anticancer cells.

Keywords:

Transcription factor
Cell biology
STAT4
IRF1
Biology
Molecular pathway
Interleukin 3

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