MP01-06 EFFECTS OF POLOXAMER-BASED THERMO-SENSITIVE SOL-GEL ON URETHRAL STRICTURE AFTER TRANSURETHRAL RESECTIONS OF THE PROSTATE FOR BENIGN PROSTATIC HYPERPLASIA : A MULTICENTER, SINGLE BLINDED, RANDOMIZED CONTROLLED STUDY

INTRODUCTION AND OBJECTIVES:A thermo-sensitive anti-adhesive with a property of sol-gel transition was manufactured by a physical mixture of Poloxamer, Chitosan and Gelatin. Poloxamer-based thermo-sensitive sol-gel has been developed to reduce the incidence of postoperative adhesion formation. The purpose of this study was to evaluate the effect of poloxamer-based thermo-sensitive sol-gel instillation after transurethral resection of the prostate (TURP) on preventing urethral stricture.METHODS:A total of 198 patients underwent TURP for benign prostatic hyperplasia.Recruited patients were randomly divided into two groups: Groups A and B. Patients in group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation, and patients in the group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of poloxamer-based thermo-sensitive sol-g...