Spiro metalloprotease inhibitors.

The invention relates to compounds useful as inhibitors of metalloproteinases and represented by the general formula (I) AS IS IS CLAIMED BUT ALSO ONE OF ITS OPTICAL ISOMERS, one of its diastereoisomers or enantiomers, into one of their pharmaceutically ACCEPTABLE OR ALSO ONE OF HIS ALCOXIAMIDAS biohydrolyzable A ester thereof, or one of its imides. The invention also relates to compounds, pharmaceutical compositions YA therapies directed against diseases, disorders and conditions characterized by metalloprotease ACTIVITY, such therapies involve the use of these compounds or the pharmaceutical compositions containing these compounds.