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Neil Gregory Almstead

Procter & Gamble

71

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1118

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In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren.

2020 Pharmacology Research & Perspectives
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Metabolism and Disposition of Ataluren following Oral Administration to Mice, Rats, Dogs, and Humans

2020 Drug Metabolism and Disposition
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Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria

2018 Journal of Medicinal Chemistry
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Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

2016 Journal of Medicinal Chemistry
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Abstract 2529: Optimization of small molecules targeting BMI1 protein expression. Part 1. Amino-thiazoles: the first-in-class highly potent inhibitors of BMI1 protein

2014 Cancer Research
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SMN2 Gene Splicing Modifiers Restore Lifespan and Motor Behavior in a Mouse Model of Spinal Muscular Atrophy.

2014
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Abstract 2528: Optimization of small molecules targeting BMI1 protein expression. Part 2. Improved potency, oral bioavailability, and in vivo efficacy of amino-pyrazines and amino-pyridines

2014 Cancer Research
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Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4-d]pyrimidines

2013 Organic Letters
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Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity

2013 Synthesis
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