In vitro effect of glucan on mouse hemopoietic committed progenitor cells

Abstract In vitro methylcellulose clonal cell culture assays of granulopoietic and erythropoietic colonies were used to study the primary effect of glucan on the hematopoietic stem cells. Addition of glucan to the cultures inhibits the formation of colony-forming units-erythrocytic (CFU-E), enhances the production of burst forming units-erythrocytic (BFU-E) and has no effect on colony-forming unit-culture (CFU-C). These results indicate that glucan has a direct effect on late and early erythroid precursor cells.