EVALUATION OF THE ANTI-INFLAMMATORY CAPACITY OF BETA-SITOSTEROL IN RODENT ASSAYS
2016
Background: Beta-sitosterol (BS) is a compound discovered to be present in numerous plants. A number of interesting
biomedical properties have been attributed to BS, including immuno-modulating and anti-inflammatory activities.
Therefore, the aim of this report was to evaluate its anti-inflammatory capacity by applying various rodent
experimental tests.
Methods. To carry out the objective of the study we applied the methods indicated here. Two of the adopted methods
were based on the passive reverse Arthus reaction: the rat paw edema test and the rat pleurisy assay. We also applied
two methods related with the non-specific acute inflammation: the mouse ear edema test, and the mouse
mieloperoxidase activity assay.
Results. The results obtained in all tests established a significant anti-inflammatory potential of BS. In the rat paw
edema test we found an inhibitory effect which goes from 50-70%; in the rat pleurisy assay our findings with respect to
the volume of pleural exuded showed a reduction of 46%, as well as a 20% low amount of neutrophils in comparison
with the level of the control group. In the mouse ear edema test we found a mean inflammatory inhibition of 75%, and
with respect to mieloproxidase activity the results showed a significant inhibition induced by the three doses of BS.
Conclusions. In the present study we determined a potent anti-inflammatory capacity of BS in specific and nonspecific
types of acute inflammation in rodents.
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