pH-Sensitive Chitosan–Sodium Phytate Core–Shell Hollow Beads and Nanocapsules for the Encapsulation of Active Ingredients

The oral administration of nutraceuticals and vitamins is the most compliant route because of its minimal invasiveness, painlessness, ease of use, and cost effectiveness. To overcome the possible destruction and low availability induced by the harsh gastrointestinal environment, we use sodium phytate as a cross-linker to fabricate pH-sensitive core–shell chitosan hollow beads and nanocapsules through the ionic linking method for the controllable release of active ingredients. Texture profile analysis, transmission electron microscopy, dynamic light scattering, and scanning electron microscopy were used to characterize the morphologies and behaviors of the beads and nanocapsules. The size of the beads could be adjusted from 0.1 to 10 mm, and the diameter of the nanocapsules was 50–100 nm. The addition of pectin in sodium phytate remarkably increased the hardness of the chitosan beads. Nile blue A was used as a model active ingredient for loading into the chitosan beads with the maximum encapsulation effici...