Enterotoxin Effect on Hepatocytes in Experimental Intestinal Obstruction in the Rat

Thirty-two Wistar rats were studied for liver injury caused by enterotoxemia due to experimental intestinal obstruction. In the experimental group, enterotoxin titers were measured1.83±0.38, 2.40±0.39, 10.80±2.97(M±SE) in the group of the duration of intestional obstruction for 2-,4-,and started form Zone 3 and then extended into Zone 1with prolonged obstruction. The experimental group which experienced the longest period of obstruction also exhibited elevated serum GPT and GOT levels. The severity of damage increased with time of obstruction. The disturbance of liver cells in attention in the management of intestional obstruction from this animal model.