The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

Johanna Giuranna,Anna-Lena Volckmar,Anna Heinen,Triinu Peters,Börge Schmidt,Anne Spieker,Helena Straub,Harald Grallert,Timo D. Müller,Jochen Antel,Ute Haußmann,Hans Klafki,Rui Liangyou,Johannes Hebebrand,Anke Hinney

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

2018

Johanna Giuranna
Anna-Lena Volckmar
Anna Heinen
Triinu Peters
Börge Schmidt
Anne Spieker
Helena Straub
Harald Grallert
Timo D. Müller
Jochen Antel
Ute Haußmann
Hans Klafki
Rui Liangyou
Johannes Hebebrand
Anke Hinney

Objective We aimed to determine the effect of human SH2B1 variants on leptin and insulin signaling, which are major regulators of energy homeostasis, on the RNA level.

Keywords:

Endocrinology
SH2B1
Internal medicine
Insulin
Diabetes mellitus
Leptin
Hypothalamus
Medicine
Protein kinase B
Insulin receptor
Energy homeostasis
Gene
SORBS1
Mutation

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