SH2B1

2HDV, 2HDX2597020399ENSG00000178188ENSMUSG00000030733Q9NRF2Q91ZM2NM_001308294NM_015503NM_001289542NM_011363NP_001295223NP_056318NP_001276471NP_035493SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.2hdv: Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B2hdx: Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene. SH2B1 has been shown to interact with: Variations close to or in the SH2B1 gene have been found to associatate with obesity in two very large genome wide association studies of body mass index (BMI). Furthermore, SH2B1 deletions are associated with severe early-onset obesity.