What's new in vitamin D for the nephrologist?

The parathyroid glands synthesize and secrete parathyroid hormone (PTH ) in response to low calcium, low 1,25-dihydroxyvitamin D 3 (calcitriol ), and high phosphate concentrations. The interplay between these The vitamin D receptor elements is complex, operating through several feedback mechanisms. Both PTH and calcitriol regulate Calcitriol mediates its genomic eVects through the circulating calcium and phosphate concentrations vitamin D receptor ( VDR), which is a member of the through their action on target organs, namely the steroid/thyroid superfamily of nuclear receptors. kidney, bone, and intestine. PTH and calcitriol regulate Calcitriol binding to VDR results in changes in tranone another’s production, and additionally are both scription rates for those genes that contain vitamin D regulated separately by extracellular calcium and phos- responsive elements ( VDREs). There are many other