Targeting Her2-insYVMA with Covalent Inhibitors – A Focused Compound Screening and Structure-Based Design Approach

Jonas Lategahn,Julia Hardick,Tobias Grabe,Janina Niggenaber,Kirujan Jeyakumar,Marina Keul,Hannah L. Tumbrink,Christian F. W. Becker,Luke Hodson,Tonia Kirschner,Philip Klövekorn,Julia Ketzer,Matthias Baumann,Susanne Terheyden,Anke Unger,Jörn Weisner,Matthias P. Müller,Willem A. L. van Otterlo,Sebastian Bauer,Daniel Rauh

Targeting Her2-insYVMA with Covalent Inhibitors – A Focused Compound Screening and Structure-Based Design Approach

2020

ABSTRACT: Mutated or amplified Her2 serves as a driver of non-small cell lung cancer (NSCLC) or mediates resistance toward the inhibition of its family member EGFR (epidermal growth factor receptor...

Keywords:

non small cell
Cancer research
Chemistry
structure based
Covalent bond
family member
Epidermal growth factor receptor

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