High glucose stimulates cell proliferation and Collagen IV production in rat mesangial cells through inhibiting AMPK-K ATP signaling

Bei Zhang,Yongquan Shi,Jun-jie Zou,Xiangfang Chen,Wei Tang,Fei Ye,Zhimin Liu

High glucose stimulates cell proliferation and Collagen IV production in rat mesangial cells through inhibiting AMPK-K ATP signaling

2017

Bei Zhang
Yongquan Shi
Jun-jie Zou
Xiangfang Chen
Wei Tang
Fei Ye
Zhimin Liu

Purpose The present study investigated the putative mechanisms underlying effects of KATP channel on high glucose (HG)-induced mesangial cell proliferation and tissue inhibitors of metalloproteinases (TIMP)-2 and Collagen IV production.

Keywords:

Urology
AMP-activated protein kinase
Diabetes mellitus
Cell biology
Matrix metalloproteinase
Endocrinology
AMPK
Mesangial cell proliferation
Cell growth
Internal medicine
Medicine
Kinase
Diazoxide
Protein kinase A
Patch clamp

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