In vivo efficacy and toxicity studies on Erythrina senegalensis and Khaya ivorensis used as herbal remedies for malaria prevention in Cameroon.

Aim: The study aimed at assessing the in vivo anti-plasmodial activity of aqueous extracts from Erythrina senegalensis and Khaya ivorensis , two plants used traditionally as bark decoctions in Cameroon to prevent and cure malaria. Methodology: The antiplasmodial activity of aqueous extracts of E. senegalensis and K. ivorensis was investigated using a murine malaria model ( Plasmodium berghei / Anopheles stephensi / BALB/c mice), applying a protocol for assessing the prophylactic potential of the remedy. Treatments were administered orally to BALB/c mice for 9 days at doses of 200 and 400 mg/kg/day. Mice were challenged on day 3 of treatment by