The association between human papillomavirus (HPV) types infection and the cervical lesions

Objective To investigate the human papillomavirus (HPV) types detected in outpatient women and patients with cervical lesions, and to analyze the oncogenesis of the various HPV types.Methods A total of 1715 outpatient women were checked for 21 HPV DNA types by DNA flow-through hybridization genotyping technique, 463 women who undergo colposcopy and cervical biopsy were collected. According to the pathological diagnosis, the patients were divided into four groups: 234 in inflammatory group, 96 in CINⅠ group, 80 CINⅡ and 53 CINⅢ. The association between HPV types and different cervical lesions was analyzed.Results All of 21 types HPV were detected, the infection rates of outpatient women, women with cervical lesions and patients with CINⅢ, were 57.1% (978/1715), 76.9% (356/463) and 98.1%(52/53) respectively. HPV 16 was the most common type, the other common types(in descending order of frequency): in outpatient women 58,52,33 and 6,in patients with cervical lesions 58, 52, 33 and 31, in CINⅢ 33, 58, 31 and 52. By logistic regression, the high-grade squamous intraepithelial lesions (HSIL, CINⅡ + CINⅢ) was associated with detection of HPV 16, 33 and 31 (OR 9.59, 2.99 and 2.52, 95%CI 4.805～11.989, 1.231～7.296 and 1.174～5.429). Conclusions HPV types 16, 58, 52, 33 and 31 are more common in cervical lesions, the major pathogenic types were HPV 16, 33 and 31.