cAMP potentiates β-amyloid-induced nitric oxide release from microglia

THE β-amyloid peptide (Aβ) has been known to activate microglia and to induce release of nitric oxide (NO). In this study, we examined the effect of cAMP on Aβ-induced microglial activation using cultured rat brain microglia. Dibutyryl-cAMP (dbcAMP) and 3-isobutyl-1-methylxanthine (IBMX) significant