Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease

Introduction: T2DM and CAD poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. Amylin is a fraternal twin of insulin, it has a great potential to fibrillation, aggregate formation, and deposition causes proteotoxicity to the vital organs. Aim: To find the association of amylin with inflammatory markers in T2DM with CAD subjects. Methodology: Present cross sectional study conducted on 262 subjects (30-60 years); including T2DM with angiographically diagnosed CAD cases (n=131) and healthy controls (n=131). The diabetic and lipid profile were estimated and Amylin, Insulin, hsCRP, TNF-α, and IL-6 levels assessed by ELISA. Ethical approval & written informed consent were obtained. Subjects with inflammatory disorders were excluded. Data analysed on SPSS-24, the Descriptive Statistics performed for p≤0.05 (95% CI). Association between variables and AUC of ROC were performed. Results: BSL-F/PP, HbA1c, HOMA-IR, TC, TG, LDL-C, VLDL-C and Non-HDL-C) were significantly raised, whereas QUICKI and HDL-C decreased (p