TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Daniele V.F. Tauriello,Sergio Palomo-Ponce,Diana Stork,Antonio Berenguer-Llergo,Jordi Badia-Ramentol,Mar Iglesias,Marta Sevillano,Sales Ibiza,Adrià Cañellas,Xavier Hernando-Momblona,Daniel Byrom,Joan A. Matarin,Alexandre Calon,Elisa I. Rivas,Angel R. Nebreda,Antoni Riera,Camille Stephan-Otto Attolini,Eduard Batlle

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

2018

Daniele V.F. Tauriello
Sergio Palomo-Ponce
Diana Stork
Antonio Berenguer-Llergo
Jordi Badia-Ramentol
Mar Iglesias
Marta Sevillano
Sales Ibiza
Adrià Cañellas
Xavier Hernando-Momblona
Daniel Byrom
Joan A. Matarin
Alexandre Calon
Elisa I. Rivas
Angel R. Nebreda
Antoni Riera
Camille Stephan-Otto Attolini
Eduard Batlle

A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice.

Keywords:

Immune system
Metastasis
Metastatic tumours
Cytotoxic T cell
Colorectal cancer
Cancer research
Medicine
Immune checkpoint
Stem cell
Immunotherapy
Transplantation

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