Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

Joanna H. Tong,David Ng,Shuk L. Chau,Ken K So,Patrick P.S. Leung,Tin L Lee,Raymond Wai-Ming Lung,Michael W.Y. Chan,Anthony W.H. Chan,Kwok W. Lo,Ka F. To

Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

2010

Joanna H. Tong
David Ng
Shuk L. Chau
Ken K So
Patrick P.S. Leung
Tin L Lee
Raymond Wai-Ming Lung
Michael W.Y. Chan
Anthony W.H. Chan
Kwok W. Lo
Ka F. To

Background Human Disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal carcinoma (NPC).

Keywords:

Bisulfite sequencing
Carcinoma
Cancer research
Gene expression profiling
Suppressor
Hedgehog signaling pathway
Nasopharyngeal carcinoma
DNA methylation
Nasopharyngeal neoplasm
Molecular biology
Biology
Surgical oncology
Stem cell
Tumour suppressor gene
promoter hypermethylation

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