Physiopathological relevance of cannabinoid CB₁ receptor in the development of glutamatergic and gabaergic populations during cortical ontogeny

The brain is the most complex organ in the body. Given the amount of information that it has to compute and integrate in behavioural and somatic responses, it comes as no surprise the enormous amount of different cells and circuit assemblies that build it up. All this diversity originates from a relatively small amount of undifferentiated stem cells that undergo an intricate development proccess culminating with a mature brain. Hundreds of molecules and signalling systems orchestrate consecutive waves of progenitor cell proliferation, their differentiation in the specific cell lineages that populate the cerebral parenchyma, as well as the migration of their progeny from the germinative niches in which they are born to the definitive areas they will occupy in the adult brain...