High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells

Yuji Takihara,Ayako Nakamura-Ishizu,Darren Qiancheng Tan,Masahiro Fukuda,Takayoshi Matsumura,Mitsuhiro Endoh,Yuichiro Arima,Desmond Wai Loon Chin,Terumasa Umemoto,Michihiro Hashimoto,Hidenobu Mizuno,Toshio Suda

High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells

2019

Yuji Takihara
Ayako Nakamura-Ishizu
Darren Qiancheng Tan
Masahiro Fukuda
Takayoshi Matsumura
Mitsuhiro Endoh
Yuichiro Arima
Desmond Wai Loon Chin
Terumasa Umemoto
Michihiro Hashimoto
Hidenobu Mizuno
Toshio Suda

Key Points HSCs can be separated based on high or low mitochondrial mass. Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.

Keywords:

Stem cell
Cell biology
Haematopoiesis
Biology
Chemistry
Cell cycle quiescence
Mitochondrion

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