Патогенетичне значення центральної моноамінергічної нейропередачі в механізмах розвитку моторних дисфункцій та неврологічного дефіциту після легкої черепно-мозкової травми

Motor reactions, muscular and coordinative activity together with neurologic deficit dynamic were investigated in rats 35 days after light brain trauma in conditions of serotonin-, dopamine- and noradrenergic neurotransmitter systems activity modulation. Neurological deficit indexes were studied in time-dependent regime. Brain traumainduced muscle atony, failure in normal posture keeping and synchronous coordinative movements was shown to be evident in conditions of both dopamine- and serotoninergic neurotransmission activation. Dopaminergic neurotransmitter system activity suppression results in rats failure to demonstrate any motor activity throughout 14 days of posttraumatic period. Serotoninergic neurotransmitter system suppression and noradrenergic neurotransmitter system activity modulation also failed to influence on the traumatized rats investigated functions. The conclusion was done about dopamine- and serotoninergic (in the smaller degree) neurotransmitter systems pathogeneteic role in motor and neurologic deficit formation in rats during the posttraumatic period. These positions should be taken into consideration in case of light brain trauma-provoked abovementioned disturbances pathogenetically proved schemes of pharmacological correction performing out. Key words: light brain trauma, central monoaminergic neurotransmitter systems, motor activity, neurologic deficit, pathogenetic importance, complex pathogenetically proved pharmacological correction