Monoaminergic means 'working on monoamine neurotransmitters', which include serotonin, dopamine, norepinephrine, epinephrine, and histamine. Monoaminergic means 'working on monoamine neurotransmitters', which include serotonin, dopamine, norepinephrine, epinephrine, and histamine. A monoaminergic, or monoaminergic drug, is a chemical which functions to directly modulate the serotonin, dopamine, norepinephrine, epinephrine, and/or histamine neurotransmitter systems in the brain. Monoaminergics include catecholaminergics (which can be further divided into adrenergics and dopaminergics), serotonergics, and histaminergics. An example of a class of monoaminergic drugs is monoamine oxidase inhibitors (MAOIs).