Cellular and molecular basis of beta-amyloid precursor protein metabolism.

1. Abstract 2. Introduction 3. Discussion 3.1. beta APP Structure Gives Clues to its Function 3.2. beta APP is Trafficked and Processed Through the Secretory Pathway 3.3. alpha-Secretase Cleaves beta APP at the Cell Surface 3.4. Alternative beta APP Metabolism Gives Rise to Amyloid-beta Peptides 3.5. Abeta Peptides may be Generated Intracellularly 3.6. FAD Mutations and the beta -secretase 3.7. Role of Presenilin in Abeta Generation and AD Pathogenesis 3.8. Signal Transduction Regulates beta APP Trafficking 3.9. Hormonal Regulation of beta APP Metabolism 4. Perspective (AU: change OK?) 5. Acknowledgement 6. References