Cells, cell lines and non-human animal model for the determination of therapeutic agents.

Cells, cell lines and non-human animal model for the determination of therapeutic agents. # The present invention describes mesenchymal stem cells isolated differentiated osteogenic progenitor genetically modified by deletion of sequences or a fragment of the sequences encoding for protein p53 and the Rb protein. The cells described herein also have the ability to cause tumors in vivo osteosarcoma type. In the present invention are also described lines and cell populations, as well as an animal model to which is said stem cells have been implanted osteosarcoma-like. Similarly, the present invention discloses the method for obtaining such cells and uses, preferably for screening agents useful in the treatment and / or prevention sarcoma.