p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

In a mouse model, it is found that the loss of the tumour suppressors p53 and Pten leads to the development of tumours resembling human primary glioblastomas, and both p53 and PTEN are frequently lost in the human cancer. Loss of these tumour suppressors impairs the differentiation of neural stem cells, due to upregulation of Myc by the concerted action of p53 and PTEN loss.