Assessing the impact of Cyclosporine A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex-vivo gene therapy settings

Carolina Petrillo,Andrea Calabria,Francesco Piras,Alessia Capotondo,Giulio Spinozzi,Ivan Cuccovillo,Fabrizio Benedicenti,Luigi Naldini,Eugenio Montini,Alessandra Biffi,Bernhard Gentner,Anna Kajaste-Rudnitski

Assessing the impact of Cyclosporine A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex-vivo gene therapy settings

2019

Carolina Petrillo
Andrea Calabria
Francesco Piras
Alessia Capotondo
Giulio Spinozzi
Ivan Cuccovillo
Fabrizio Benedicenti
Luigi Naldini
Eugenio Montini
Alessandra Biffi
Bernhard Gentner
Anna Kajaste-Rudnitski

Improving hematopoietic stem and progenitor cell (HSPC) permissiveness to lentiviral vector (LV) transduction without compromising their biological properties remains critical for broad-range imple...

Keywords:

Virology
Ex vivo gene therapy
Cancer research
Stem cell
Haematopoiesis
Transduction (genetics)
Biology
Viral vector
Progenitor cell
Permissiveness
lentiviral transduction
cyclosporin a
Cell biology

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