Solubilization of capsaicin and its nanoemulsion formation in the sonication and self-assembly methods

In this research, we investigated the optimum condition for the preparation of O/W nanoemulsion containing surfactants and oleoresin capsicum(OC) in fourcomponent systems, and characterized the structure and stability of nanoemulsions by using the ternary phase diagrams of systems. Various types of nanoemulsion including single-layer, double-layers and triple-layers nanoemulsions could be produced depending on the polyelectrolytes such as alginate and chitosan. O/W nanoemulsions of OC could be prepared by the ultrasonication process at the ration of mixture of OC:Tween 80(1:0.7) and by self-assembly method at the ratio of mixture of OC:Tween 80(1:3) with a particle size of 20100nm and having a good stability during storage. The ultra-sonication method may be more powerful tool to prepare the nanoemulsion than the self-assembly process, it might be due to the formation capacity of nanoemulsion phase.