Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) Mice Transplanted with CD34+ Human Hematopoietic Stem Cells

Sundeep Chandra,Patrizia Cristofori,Carlos Fonck,Charles A. O'Neill

Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) Mice Transplanted with CD34+ Human Hematopoietic Stem Cells

2019

Sundeep Chandra
Patrizia Cristofori
Carlos Fonck
Charles A. O'Neill

A therapeutic option for monogenic disorders is gene therapy with ex vivo-transduced autologous hematopoietic stem cells (HSCs). Safety or efficacy studies of ex vivo-modified HSCs are conducted in...

Keywords:

Ex vivo gene therapy
Stem cell
CD34
Haematopoiesis
Graft-versus-host disease
Endocrinology
Cancer research
Internal medicine
Nod
Biology
Genetic enhancement
Ex vivo
Humanized mouse

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