Effects of glistenings in intraocular lenses

Glistenings consist of multiple microvacuoles in intraocular lenses (IOLs) that cause retinal stray light and may affect quality of vision. For four IOL types, the microvacuole particle size distribution and particle volume density was measured using confocal light microscopy and dark field microscopy, and the corresponding extinction coefficient γ was determined. The light scatter contribution induced by microvacuoles was measured as function of both angle and extinction, and was verified by calculations using Mie theory. Two IOL types possessed significant glistenings having stray light levels higher than that of a healthy 20 year old crystalline lens corresponding to γ ≥ 0.08 mm−1.