Современные маркеры в диагностике пищевой непереносимости у детей грудного возраста

Background. Despite new treatment methods and diagnostics of food intolerance in infants, it is still difficult to make a diagnosis. The research objective is to identify a diagnostics value of endogenic peptide and protein determination in blood serum and coprofiltrates in infants suffering from food intolerance (FI). Methods. There were examined 30 infants with allergic enteropathy (cow's milk protein intolerance) and 30 infants with secondary lactase deficiency at age 6-12 months (control group 20 healthy infants). Zonulin, eosinophilic cationic protein, s-defensin 2, and transthyretin content were determined in coprofiltrates; fatty acid-binding proteins, and membrane permeability-increasing protein. Results. Twofold increase in coprofiltrates content of s-defensin 2, and zonulin says for cow's milk protein intolerance. Intestinal absorption abnormality were attended by intestinal and liver fatty acid-binding proteins increase (max level was registered at allergic enteropathy) in blood serum. Membrane permeability-increasing protein level occurred to be an informative measure of cow's milk protein intolerance. Conclusions. Achieved results broaden the vision about the pathogenesis of food intolerance. The use of these markers will improve the diagnostics, and avoid aggressive approach in the range of cases. Implementation of these methods will improve the diagnostics, disease prognosis and possibility of adequate therapy of food intolerance in infants.