Low-dose oral cholecalciferol is associated with higher numbers of Helios + and total Tregs than oral calcitriol in renal allograft recipients: an observational study

Background Regulatory T cells (Tregs) are a cornerstone of graft acceptance. High numbers of Tregs are associated with better long-term graft survival. Recently, Vitamin D was suggested as an immunomodulator, in addition to its classical role in calcium metabolism. Vitamin D modulates Tregs and might, thereby, promote graft acceptance and long-term graft survival.