[Analysis of Indicators Related with Cell Proliferation and Apoptosis in the Patients with B Cell Non-Hodgkin's Lymphoma].

To analyze the indicators related with cell proliferation and apoptosis in patients with B cell non-Hodgkin's lymphoma(B-NHL).Seventy-two cases of B-NHL and 50 cases of reactive hyperplasia of lymph nodes were entrolled in the experimental group and control group respectively. The expression levels of proliferating cell nuclear antigen(PCNA), X-linked inhibitor of apoptosis(XIAP) and B cell lymphoma leukemia-2(BCL-2) in paraffin-embedded tissue samples of 2 groups were detected by immuno-histochemistry staining, and their ralationship with pathologic factors was analyzed.The positive cell rates of PCNA, XIAP and BCL-2 in experiment group were significantly higher than those in control group (P 0.05). The progression-free survival(PES) time in PCNA low positive expression group was longer than that in PCNA high positive expression group(P 0.05); the PFS time also was not significantly different between B-NHL patients with BCL-2 positive and negative expression(P>0.05).All the PCNA, XIAP and BCL-2 participate in the pathngenesis of B-NHL, among them the positive level of PCNA obviously influences the clinical staging of B-NHL.