The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens
2011
We describe a fully automated and autonomous air-borne biothreat detection system for biosurveillance applications.
The system, including the nucleic-acid-based detection assay, was designed, built and shipped by Microfluidic Systems
Inc (MFSI), a new subsidiary of PositiveID Corporation (PSID). Our findings demonstrate that the system and assay
unequivocally identify pathogenic strains of Bacillus anthracis, Yersinia pestis, Francisella tularensis , Burkholderia
mallei , and Burkholderia pseudomallei . In order to assess the assay's ability to detect unknown samples, our team also
challenged it against a series of blind samples provided by the Department of Homeland Security (DHS). These samples
included natural occurring isolated strains, near-neighbor isolates, and environmental samples. Our results indicate that
the multiplex assay was specific and produced no false positives when challenged with in house gDNA collections and
DHS provided panels. Here we present another analytical tool for the rapid identification of nine Centers for Disease
Control and Prevention category A and B biothreat organisms.
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